Endocrine Abstracts

Introduction: Poems Syndrome is a rare multisystem disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma-proliferative disorder and skin changes, among other features. Literature describes endocrine abnormalities at least in 93% of patients with Poems Syndrome during the diagnosis as well as during the follow-up. The most common deficiencies ranked by their frequency are hypogonadism, hyperprolactinemia, hypothyroidism, abnormal glucose meta...

Introduction: Grave’s disease (GD) is an autoimmune disease characterized by the development of thyroid-stimulating hormone (TSH) receptor antibodies that have a stimulating effect on the thyroid gland. There is a rare but non-incidental and well-documented association between GD and thymic hyperplasia (TH). Nonetheless, this association is often underdiagnosed in routine clinical practice and the mechanisms behind this association have yet to be thoroughly elucidated. Th...

Introduction: Terlipressin is a non-selective vasopressin analogue used in patients with decompensated cirrhosis, gastrointestinal haemorrhage or hepatorenal syndrome. It directly binds to V1 receptors improving circulatory volume by causing splanchnic vasoconstriction and portal hypertension inhibition, and has a full V2 receptor agonism in the collecting duct. In consequence, it increases reabsorption of water and can lead to a decrease in plasma osmolality and hyponatremia....

Background: T2-weighted magnetic resonance imaging (MRI) signal has been recently linked with a better tumor response to pasireotide treatment in patients with acromegaly (ACRO). Our aim was to evaluate the prevalence of this radiological feature and its association to therapeutic outcomes in a large cohort of ACRO patients treated with pasireotide.Methods: A retrospective multicentre study was performed in 15 Spanish tertiary university hospitals includ...